Automatic detection of amyloid plaques on ex vivo APP/PS1 mouse brain using a zoom T2-weighted spin echo sequence
نویسندگان
چکیده
Introduction Amyloid plaques are known as a marker of Alzheimer's disease. They are traditionally detected as hypointense spots on T2-weighted images taking advantage of the susceptibility effect due to iron embedded inside them. However it has been recently reported that T2 contrast might be more efficient to detect cortical amyloid plaques [1]. In this context, the goal of the present study was to compare two different strategies: (i) a conventional T2 gradient echo sequence with volume coil [2], and (ii) a zoom adiabatic T2 spin echo sequence with surface coil [1]. The images of an ex vivo APP/PS1 mouse brain acquired with both approaches were compared based on their ability to allow successful plaques detection using a home-made automatic procedure.
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